The Unit participates in the project of the first bio-artificial pancreas, developed by the Defymed company, which involves laboratories and firms from Alsace and Lorraine.
This bio-artificial pancreas, named MAILPAN® can be implanted for the treatment of type 1 diabetic patients in Europe.
The MECABARP project is programmed for 3 years and its aim is to understand the behaviour of MAILPAN®. It involves testing the resistance and impermeability of the different components before MAILPAN® enters into clinical phase trials in man.
The Unit studies the mechanical resistance of membranes and MAILPAN® until rupture after explanting into the mini-pig, on existing trial benches under normal conditions or after aging in vivo.
This is a project that brings high hopes for patients with type 1 diabetes. While improving considerably their quality of life, it should provide many advantages: physiological control of diabetes, transplantation of pancreatic islets without treatment with an immuno-suppressor, routine visit to a diabetes clinic every 3 to 6 months, ending the multiple daily injections with insulin, reduction in long-term diabetic complications thanks to the normalization of glycaemia.
This project consists of using a highly intense and penetrating X-ray beam supplied by the ESRF (European Synchrotron Radiation Facility) in Grenoble to study the transformations of a metallic material in real time and in massive objects.
The idea is to succeed in the construction, at the Synchrotron site, of a light beam dedicated to "metallurgy"
Such a beam would allow the researchers of the Université de Lorraine to carry out experiments that are impossible today, such as observing the first solid seeds in a liquid metal during cooling, or measuring the constraints in an alloy during its development and shaping.
This project also interests industrial researchers: for example, the systematic use of synchrotron radiation should allow them to gain three years during the development of a new metal alloy for the automobile, aviation or energy sectors.
The LabEx DAMAS (LABoratory of EXcellence Design of Alloy Metals for low-mAss Structures) is a laboratory of excellence that encompasses the metallurgists of the LEM3 laboratory and the Institut Jean Lamour.
Within the LabEx, our Unit developed a new composite; reversibly cross-linked Polypropylene (PP) (recyclable):
- microstructural characterization
- thermomechanical properties
- behaviour laws
- static and dynamic numerical simulation (polymer film alone, hot-melt polymer film on a steel strip)
- study of the influence of adding elastomer particles (EPR, EPDM, etc.) and nanometric metallic particles (copper) on the properties-microstructures-behavioural laws relationship.