[Article] - Caractérisation de nanoparticules d'oxyde de fer superparamagnétique par relaxométrie RMN à cycle de champ rapide
We report the nuclear magnetic resonance dispersion (NMRD) profile of superparamagnetic iron oxide nanoparticles (SPIONs) and compare the values obtained from its analysis with those from standard methods. Recorded at 1H Larmor frequencies from 10 kHz to 600 MHz (0.23 mT to 14.1 T, static magnetic field), this profile covers water 1H dynamics across a broad timescale encompassing all medically relevant magnetic field strengths in magnetic resonance imaging (MRI). This extensive coverage enables the extraction of accurate physicochemical parameters of the nanoparticles that dictate their efficiency (relaxivity). To support this approach, other conventional characterization methods, including TEM, DLS/zeta potential, and VSM, were employed and compared with the NMRD findings. To ensure robustness, the NMRD profiles were recorded at both 25°C and 37°C.
Analysis of NMRD profiles, in conjunction with the appropriate theoretical model, successfully characterized SPIONs, yielding coherent parameters that compare favorably with those from conventional characterization methods.
Titre complet : Characterization of Ultrasmall Superparamagnetic Iron Oxide via Fast Field-Cycling NMR Relaxometry at Two Temperatures
Auteurs de l’article : Lyns Verel Che Dji, Thomas Girardet, Solenne Fleutot, Sabine Bouguet-Bonnet
Références de l’article : Magnetic Resonance in Chemistry, 2026; 64:312–318
