[Article] Targeted and Smart superparamagnetic core/shell nanoparticles were developed in the frame of cancer therapy
Abstract
The group has demonstrated a versatile strategy to engineer smart theranostic nanocarriers. Core/shell nanosystem composed of a superparamagnetic iron oxide (Fe3−δO4) nanoparticle on which P(MEO2MAx-OEGMA100−x) copolymer was grown from the surface. The grafting of Folic acid (FA) at the polymer chain end lead to provide an efficient active targeting of NPs to cancer cells. The control of the drug loading an release of the nano-object was assessed and full drug (100%) is released after 52 h at 41 °C. Moreover this work found that P(MEO2MA60-OEGMA40) polymers lead to a surface that exhibits interesting stealth behavior against Human Serum Albumin and Fibrinogen model proteins.
Authors
Zied Ferjaoui, Sara Nahle, Raphaël Schneider, Halima Kerdjoudj, Damien Mertz, Fabienne Quilès, Khalid Ferji, Eric Gaffet, Halima Alem
References
Adv. Mat. Interf. Volume10, Issue12, année 2023
Pages : 2202364
DOI