[Article] From microwave synthesis to biological characterization of MRI contrast agents

Sous titre
SPIONs magnetic nanoparticles for MRI applications: Microwave synthesis and physicochemical, magnetic and biological characterizations

Photo

Abstract

More and more biomedical applications used nanoparticles to improve their quality and their possibilities. The aim of this study is to obtain highly water-soluble iron oxide nanoparticles using a microwave process. After the synthesis, several characterizations are carried out to determine the shape, the size, the chemical composition, the stability and the magnetic properties. The internalization of nanoparticles and the cytotocixity are studied before measurements ofrelaxometry and MRI (Magnetic Resonance Imaging).

Authors

Thomas Girardet, Emilie Bianchi, Christel Henrionnet, Astrid Pinzano, Sabine Bouguet-Bonnet, Corentin Boulogne, Sébastien Leclerc, Franck Cleymand, Solenne Fleutot

References

Materials Today Communications 36 (2023) 106819

DOI

https://doi.org/10.1016/j.mtcomm.2023.106819